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BIDIRECTIONAL REGULATION OF NA+,K+-ATPASE ACTIVITY BY DOPAMINE AND AN ALPHA-ADRENERGIC AGONIST

被引：82
作者：
IBARRA, F
APERIA, A
SVENSSON, LB
EKLOF, AC
GREENGARD, P
机构：
[1] KAROLINSKA INST, ST GORANS CHILDRENS HOSP, DEPT PEDIAT, S-11281 STOCKHOLM, SWEDEN
[2] ROCKEFELLER UNIV, MOLEC & CELLULAR NEUROSCI LAB, NEW YORK, NY 10021 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 01期
关键词：
ALPHA-ADRENERGIC RECEPTORS; NATRIURESIS; PROXIMAL TUBULES; PHOSPHATASE INHIBITORS;
D O I：
10.1073/pnas.90.1.21
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Catecholamines have pronounced effects on the renal handling of sodium and water, dopamine-promoting sodium and water excretion, and norepinephrine-promoting sodium and water retention. In the present study, using isolated permeabilized renal tubule cells and intact rats, we have shown that these effects can be attributed to opposing actions of these transmitters on renal tubular Na+,K+-ATPase activity. The ability of each of these catecholamines to regulate Na+,K+-ATPase activity is affected by the concentration of Na+ as well as by the absence or presence of the opposing catecholamine.
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页码：21 / 24
页数：4
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