IMMUNOGENICITY STUDIES ON DIPHTHERIA TOXOID LOADED BIODEGRADABLE MICROSPHERES

被引：29

作者：

SINGH, M ^{[1
]}

SINGH, O ^{[1
]}

SINGH, A ^{[1
]}

TALWAR, GP ^{[1
]}

机构：

[1] PHARMAX CORP LTD,NEW DELHI 110020,INDIA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 85卷 / 1-3期

关键词：

VACCINE DELIVERY; IMMUNE RESPONSE; ANTIBODY TITER; POLYMER EROSION; ELISA;

D O I：

10.1016/0378-5173(92)90157-W

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Diphtheria toxoid loaded polylactide microspheres were prepared using the solvent evaporation method. The vaccine loaded microspheres were subjected to in vitro antigen release studies and in vivo immune response tests. The immunogenicity of the vaccine after microencapsulation was compared to that against diphtheria toxoid given in the conventional three injection schedule on alum as an adjuvant. The antibody response seen in the two cases is compared. The duration of the immune response from the two schedules is exhibited.

引用

页码：R5 / R8

页数：4

共 10 条

[1] CONTROLLED VACCINE RELEASE IN THE GUT-ASSOCIATED LYMPHOID-TISSUES .1. ORALLY-ADMINISTERED BIODEGRADABLE MICROSPHERES TARGET THE PEYERS PATCHES [J].