IMMUNOCYTOCHEMICAL DISTRIBUTION OF E-CADHERIN IN NORMAL AND INJURED LUNG-TISSUE OF THE RAT

被引：36

作者：

KASPER, M ^{[1
]}

HUBER, O ^{[1
]}

GROSSMANN, H ^{[1
]}

RUDOLPH, B ^{[1
]}

TRANKNER, C ^{[1
]}

MULLER, M ^{[1
]}

机构：

[1] MAX PLANCK INST IMMUNBIOL, D-79011 FREIBURG, GERMANY

来源：

HISTOCHEMISTRY AND CELL BIOLOGY | 1995年 / 104卷 / 05期

关键词：

D O I：

10.1007/BF01458132

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Affinity purified rabbit anti-mouse E-cadherin antibodies, reacting with diverse rat epithelia, were used to characterize epithelial changes in a radiation-induced fibrosis model of rat lung by immunoblotting techniques, immunoperoxidase and immunofluorescence microscopy. Immunostaining of normal rat lung tissues revealed a predominant staining of type II pneumocytes. Immunoelectron microscopy confirmed the immunohistochemical data of normal lung tissue obtained at the light microscopic level. In severely injured rat lung, we found enhanced immunoreactivity for E-cadherin at the surface of type I alveolar epithelial cells. The results suggest that E-cadherin is an adhesion molecule that is modulated after pathological alteration of the alveolar epithelium and that the antiserum may be useful for the characterization of normal and diseased rat epithelia.

引用

页码：383 / 390

页数：8

共 18 条

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BIRCHMEIER W, 1993, SEMIN CANCER BIOL, V4, P231

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