DOXORUBICIN IN ADVANCED BREAST-CANCER - INFLUENCE OF SCHEDULE ON RESPONSE, SURVIVAL AND QUALITY-OF-LIFE

被引：65

作者：

RICHARDS, MA ^{[1
]}

HOPWOOD, P ^{[1
]}

RAMIREZ, AJ ^{[1
]}

TWELVES, CJ ^{[1
]}

FERGUSON, J ^{[1
]}

GREGORY, WM ^{[1
]}

SWINDELL, R ^{[1
]}

SCRIVENER, W ^{[1
]}

MILLER, J ^{[1
]}

HOWELL, A ^{[1
]}

RUBENS, RD ^{[1
]}

机构：

[1] CHRISTIE HOSP & HOLT RADIUM INST,DEPT MED ONCOL,CANC RES CAMPAIGN,MANCHESTER,ENGLAND

来源：

EUROPEAN JOURNAL OF CANCER | 1992年 / 28A卷 / 6-7期

关键词：

D O I：

10.1016/0959-8049(92)90447-A

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The influence of scheduling of doxorubicin on response, survival and quality of life was assessed in a randomised trial in patients with advanced breast cancer, none of whom had previously received cytotoxic chemotherapy for advanced disease. 28 patients received 75 mg/m2 doxorubicin every 3 weeks for four courses (arm 1) and 31 patients received 25 mg/m2 weekly for 12 courses (arm 2). Response rates and median time to progression were similar in the two arms and median survival was 8 months in both arms. However, amongst patients receiving treatment every 3 weeks, psychological distress measured using the Rotterdam symptom checklist fell significantly over the course; no such change was observed in those treated weekly. Physical symptoms related to cancer improved during treatment similarly for both groups.

引用

页码：1023 / 1028

页数：6

共 30 条

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