ENDOGENOUS ALKALOIDS IN MAN SYNTHESIS, ANALYTICS, INVIVO IDENTIFICATION, AND MEDICINAL IMPORTANCE

被引：10

作者：

BRINGMANN, G

FEINEIS, D

FRIEDRICH, H

HILLE, A

机构：

来源：

PLANTA MEDICA | 1991年 / 57卷

关键词：

NONENZYMATIC INVIVO CHEMISTRY; THERAPEUTIC TRAPPING OF HARMFUL METABOLITES; HOMOCYSTINURIA; HYPEROXALURIA; PICTET-SPENGLER REACTION; ISOQUINOLINES; BETA-CARBOLINES; THIAZOLIDINES; CHLORAL; PENICILLAMINE; VITAMIN-B6;

D O I：

10.1055/s-2006-960233

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The in vitro and in vivo condensation of endogenous (or administered) reactive amines and carbonyl compounds is reported, leading to alkaloid-type heterocycles. The spectrum of the presented "mammalian alkaloids" ranges from isoquinoline derivatives, via beta-carbolines, through to thiazolidines, arising from vitamin B6, chloral, and glyoxylic acid, respectively. Formation of these compounds may occur accidentally, but might also be induced intentionally, as a therapy for metabolic diseases.

引用

页码：S73 / S84

页数：12

共 41 条

[21] UNEXPECTED REACTION-PRODUCTS OF N-METHYL-N-TRIMETHYLSILYL-TRIFLUOROACETAMIDE (MSTFA) WITH ALDEHYDES
ENDE, M
LUFTMANN, H
[J]. TETRAHEDRON, 1984, 40 (24) : 5167 - 5170
[22] FAULKNER DJ, 1986, 1 NAT PROD REP
[23] FORMATION OF TETRAHYDROPAPAVEROLINE FROM DOPAMINE IN VITRO
HOLTZ, P
WESTERMANN, E
STOCK, K
[J]. NATURE, 1964, 203 (494) : 656 - &
[24] IWASE H, 1979, CHEM PHARM BULL, V27, P1307
[25] KURZ H, 1988, PHARMAKOLOGIE TOXIKO, P47
[26] LEHNINGER AL, 1987, PRINZIPIEN BIOCH W D, P38
[27] D-PENICILLAMINE - ONCE A CONSTITUENT OF PENICILLIN - NOW A POTENT DRUG
LODEMANN, E
[J]. NATURWISSENSCHAFTEN, 1979, 66 (09) : 462 - 466
[28] LUKANOV LK, 1987, SYNTHESIS-STUTTGART, P1031
[29] MARKI HH, 1987, KLINISCHE PATHOLOGIE, P142
[30] 2,5,5-TRIMETHYLTHIAZOLIDINE-4-CARBOXYLIC ACID, A D(-)-PENICILLAMINE-DIRECTED PSEUDO-METABOLITE OF ETHANOL - DETOXICATION MECHANISM FOR ACETALDEHYDE
NAGASAWA, HT
GOON, DJW
DEMASTER, EG
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1978, 21 (12) : 1274 - 1279

← 1 2 3 4 5 →