THE ROLE OF LIPOPOLYSACCHARIDE IN COMPLEMENT-KILLING OF AEROMONAS-HYDROPHILA STRAINS OF SEROTYPE O-34

被引：44

作者：

MERINO, S ^{[1
]}

CAMPRUBI, S ^{[1
]}

TOMAS, JM ^{[1
]}

机构：

[1] UNIV BARCELONA, DEPT MICROBIOL, DIAGONAL 645, E-08071 BARCELONA, SPAIN

来源：

JOURNAL OF GENERAL MICROBIOLOGY | 1991年 / 137卷

关键词：

D O I：

10.1099/00221287-137-7-1583

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The role of lipopolysaccharide (LPS) in the susceptibility of Aeromonas hydrophila strains of serotype O:34 to non-immune human serum was investigated using isogenic mutants (serum-sensitive), previously obtained on the basis of phage resistance, and characterized for their surface components. The classical complement pathway was found to be principally involved in the serum-killing of these sensitive strains. LPS preparations from serum-resistant or serum-sensitive strains, or purified core oligosaccharides (low-molecular-mass LPS) inactivated both bactericidal and complement activity of whole serum, while the O-antigen molecules (high-molecular-mass LPS) did not. The results indicate that LPS core oligosaccharide composition contributes to complement resistance of A. hydrophila strains from serotype O:34 with moderate virulence.

引用

页码：1583 / 1590

页数：8

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