CAFFEIC ACID PHENETHYL ESTER AS A LIPOXYGENASE INHIBITOR WITH ANTIOXIDANT PROPERTIES

被引：482

作者：

SUDINA, GF

MIRZOEVA, OK

PUSHKAREVA, MA

KORSHUNOVA, GA

SUMBATYAN, NV

VARFOLOMEEV, SD

机构：

来源：

FEBS LETTERS | 1993年 / 329卷 / 1-2期

关键词：

CAFFEIC ACID PHENETHYL ESTER; 5-LIPOXYGENASE; ENZYME INHIBITION; RESPIRATORY BURST; XANTHINE OXIDASE;

D O I：

10.1016/0014-5793(93)80184-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Caffeic acid phenethyl ester, an active component of propolis extract, inhibits 5-lipoxygenase in the micromolar concentration range. The inhibition is of an uncompetitive type, i.e. the inhibitor binds to the enzyme-substrate complex but not to the free enzyme. Caffeic acid phenethyl ester also exhibits antioxidant properties. At a concentration of 10 muM, it completely blocks production of reactive oxygen species in human neutrophils and the xanthine/xanthine oxidase system.

引用

页码：21 / 24

页数：4

共 18 条

[1]

BACH MK, 1984, LEUKOTRIENES CHEM BI, P163

[2] ESTERIFICATION OF N-PROTECTED ALPHA-AMINO-ACIDS WITH ALCOHOL/CARBODIIMIDE/4-(DIMETHYLAMINO)-PYRIDINE - RACEMIZATION OF ASPARTIC AND GLUTAMIC-ACID DERIVATIVES [J].