CYTOMIMETIC ORGANIC-CHEMISTRY - EARLY DEVELOPMENTS

被引:136
作者
MENGER, FM
GABRIELSON, KD
机构
[1] Department of Chemistry, Emory University, Atlanta, Georgia
关键词
CYTOMIMETIC; ORGANIC CHEMISTRY; MICROSCOPY; SUPRAMOLECULAR CHEMISTRY VESICLES;
D O I
10.1002/anie.199520911
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
This article describes how chemical and physical stimuli cause a simple system, the giant vesicle, to undergo a variety of “cytomimetic” transformations such as fusion, fission, endocytosis, budding, aggregation, birthing, and foraging. For example, when a giant vesicle, which happens to have a smaller vesicle inside it, is exposed to octyl glucoside, the smaller vesicle can pass through the outer membrane into the external medium (“birthing”). The resulting injury to the membrane of the host vesicle heals immediately. Addition of cholic acid, on the other hand, induces a feeding frenzy in which a vesicle grows rapidly as it consumes its smaller neighbors. After the food is gone, the giant vesicle then self‐destructs (a case of “birth, growth, and death”). Such lifelike morphological changes were obtained by using commercially available chemicals; thus these processes should be assigned to organic chemistry, and not to biology or even biochemistry, and not to biology or even biochemistry. Experimental details (e.g. the preparation and observation of the vesicles) are included in this review in hopes of helping others enter this undeveloped field. Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany
引用
收藏
页码:2091 / 2106
页数:16
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