CONSTITUTIVE EXPRESSION OF C-FOS GENE INHIBITS TYPE-1 COLLAGEN-SYNTHESIS IN TRANSFECTED OSTEOBLASTS

被引：28

作者：

KUROKI, Y

SHIOZAWA, S

SUGIMOTO, T

FUJITA, T

机构：

[1] Department of Medicine, Third Division, Kobe University School of Medicine, Kobe

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 182卷 / 03期

关键词：

D O I：

10.1016/0006-291X(92)91887-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To clarify the contribution of c-fos DNA to bone formation, the effect of constitutive expression of the c-fos gene in collagen synthesis was examined by introducing c-fos DNA into osteoblastic MC3T3-E1 cells. The [3H] proline incorporation into the collagenase digestible protein(CDP) and the percent collagen synthesis were significantly decreased in the c-fos transfectants which constitutively express c-fos mRNA as compared with control transfectants. Transcription of type 1(α1) collagen gene was also specifically decreased in the c-fos transfectants. This indicates that constitutive expression of c-fos DNA interferes with bone formation by inhibiting collagen synthesis in osteoblasts. © 1992.

引用

页码：1389 / 1394

页数：6

共 21 条

[1] STRUCTURALLY DISTINCT COLLAGEN TYPES [J].