NEW APPROACHES IN ASYMMETRIC-SYNTHESIS USING GAMMA-ALKOXYBUTENOLIDES

被引：61

作者：

FERINGA, BL

DELANGE, B

JANSEN, JFGA

DEJONG, JC

LUBBEN, M

FABER, W

SCHUDDE, EP

机构：

[1] Department of Organic and Molecular Inorganic Chemistry, University of Groningen, 9747 AG, Groningen

来源：

PURE AND APPLIED CHEMISTRY | 1992年 / 64卷 / 12期

关键词：

D O I：

10.1351/pac199264121865

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of a new class of auxiliary based chiral synthons, gamma-alkoxy-2(5H)-furanones, is described. The multifunctional compounds enter a variety of asymmetric transformations leading to acyclic- and cyclic-products with up to four new stereogenic centers in a single operation with stereoselectivities exceeding 98%. Applications in new routes to an enantiomerically pure beta-lactam and lignans are given.

引用

页码：1865 / 1871

页数：7

共 29 条

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