ANCIENT CONSERVED REGIONS IN GENE-SEQUENCES

被引：15

作者：

GREEN, P

机构：

[1] Genetics Department, Washington University Medical School, St Louis, MO 63110

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1994年 / 4卷 / 03期

关键词：

D O I：

10.1016/S0959-440X(94)90110-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apart from its intrinsic interest, the elucidation of evolutionary relationships among proteins can provide useful structural and functional insights. Recent progress towards understanding the sequences that are evolutionarily conserved among diverse eukaryotes ('ancient conserved regions') include: the identification of several new ancient conserved regions; the development of more sensitive methods for detecting distant sequence relationships; and the discoveries (from analysis of new sets of genes from genome sequencing projects) that most ancient conserved regions are already represented among known proteins, and that a majority of genes do not contain such regions. These ideas are illustrated in the context of an updated analysis of the ancient conserved regions present in a 'typical' eukaryotic genomic sequence, yeast chromosome III.

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页码：404 / 412

页数：9

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