Circulating microRNAs: next-generation biomarkers for early lung cancer detection

被引：17

作者：

Bianchi, F. ^{[1
]}

Nicassio, F. ^{[1
]}

Veronesi, G. ^{[2
]}

Di Fiore, P. P. ^{[1
,3
,4
]}

机构：

[1] European Inst Oncol, Dept Expt Oncol, Milan, Italy

[2] European Inst Oncol, Div Thorac Surg, Milan, Italy

[3] FIRC Inst Mol Oncol Fdn, IFOM, Milan, Italy

[4] Univ Milan, Dipartimento Med Chirurgia Odontoiatria, Milan, Italy

来源：

ECANCERMEDICALSCIENCE | 2012年 / 6卷

关键词：

D O I：

10.3332/ecancer.2012.246

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Early diagnosis of lung cancer by low-dose computed tomography is an effective strategy to reduce cancer mortality in high-risk individuals. However, recruitment of at-risk individuals with asymptomatic lung cancer still remains challenging. We developed a minimal invasive serum test, based on the detection of circulating microRNAs, which can identify at-risk individuals with asymptomatic early stage non-small cell lung carcinomas with 80% accuracy.

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页数：5

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