HYPERAMMONEMIA AND ANOREXIA IN MORRIS HEPATOMA-BEARING RATS

被引：28

作者：

CHANCE, WT ^{[1
]}

ZHANG, FS ^{[1
]}

FOLEYNELSON, T ^{[1
]}

FISCHER, JE ^{[1
]}

机构：

[1] VET AFFAIRS MED CTR,CINCINNATI,OH 45267

来源：

PHYSIOLOGY & BEHAVIOR | 1991年 / 50卷 / 02期

关键词：

CANCER; ANOREXIA; CACHEXIA; AMMONIA; NEUROTRANSMITTERS; DOPAMINE; SEROTONIN; TYROSINE; TRYPTOPHAN; NUTRITION; FEEDING;

D O I：

10.1016/0031-9384(91)90085-3

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Inoculation of Buffalo rats with Morris hepatoma produced significant anorexia within four weeks and reduced body weight within two weeks. Blood ammonia concentration was increased by 113% when the rats were euthanized, five days after the development of anorexia. Infusing ammonium salts into normal Buffalo rats also induced anorexia at a blood ammonia concentration comparable to that observed in the tumor-bearing rats. Although ammonia-infused rats exhibited expected increases in brain tyrosine, tryptophan, and metabolites of dopamine and serotonin, these alterations were attenuated in the tumor-bearing rats. These results indicate that hyperammonemia may be a general consequence of experimental cancer and that the increase in ammonia concentration may be of primary importance in the development of experimental cancer-induced anorexia. The rather small alterations in neurotransmitter metabolism in anorectic tumor-bearing rats deemphasize the role aberrations in DA and 5-HT systems in the development of experimental cancer anorexia.

引用

页码：397 / 401

页数：5

共 26 条

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