DETECTION OF PARVOVIRUS B19 IN A SKIN BIOPSY OF A PATIENT WITH ERYTHEMA INFECTIOSUM - CASE-REPORT

被引：40

作者：

SCHWARZ, TF

WIERSBITZKY, S

PAMBOR, M

机构：

[1] UNIV GREIFSWALD,DEPT PAEDIAT,O-2200 GREIFSWALD,GERMANY

[2] UNIV GREIFSWALD,DEPT DERMATOL,O-2200 GREIFSWALD,GERMANY

来源：

JOURNAL OF MEDICAL VIROLOGY | 1994年 / 43卷 / 02期

关键词：

EXANTHEMA; EPIDERMAL CELLS; IMMUNOFLUORESCENCE; HYBRIDIZATION;

D O I：

10.1002/jmv.1890430214

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report the findings on a skin biopsy taken from a child acutely infected with parvovirus B19 showing the typical exanthematous rash. By indirect immunofluorescence with a monoclonal antibody to B19, viral capsid proteins were detected in epidermal cells localized mainly in the stratum basale. Additionally, B19 DNA was detected in epidermal cells of the stratum basale by in situ hydridization using a Dig-labelled B19 DNA probe. The detection of viral capsid proteins and viral DNA suggests the presence of complete viral particles. It is therefore concluded that B19 plays a direct role in the formation of the exanthematous rash in erythema infection. (C) 1994 Wiley-Liss, Inc.

引用

页码：171 / 174

页数：4

共 28 条

[1] HUMAN PARVOVIRUSES [J].