A DIVERGENT ROUTE TOWARD LACTAM-BASED DIPEPTIDYL BUILDING-BLOCKS

被引：8

作者：

AUBE, J

WOLFE, MS

机构：

[1] Department of Medicinal Chemistry University of Kansas, Lawrence

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 09期

关键词：

LACTAMS; OXAZIRIDINES; PEPTIDE ANALOGS; CONFORMATIONAL RESTRICTION;

D O I：

10.1016/S0960-894X(00)80589-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of chiral lactams which represent conformationally restricted peptidomimetic building blocks have been synthesized from enantiopure tert-butoxycarbonyl (Boc)-protected 2-aminocycloalkanones by (1) imine formation utilizing L-alpha-amino esters, (2) oxidation to oxaziridines, and (3) photorearrangement.

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收藏

页码：925 / 928

页数：4

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