ACYCLIC NUCLEOTIDE ANALOGS AND RELATED-COMPOUNDS

被引：10

作者：

HOLY, A

DVORAKOVA, H

机构：

[1] Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic

来源：

NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 3-5期

关键词：

D O I：

10.1080/15257779508012452

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acyclic nucleotide analogues bearing amino- and N-substituted amino groups in the side chain were prepared by alkylation of the bases with corresponding oxiranes and subsequent introduction of phosphonomethyl ether function. Novel enantiomeric synthons for the preparation of HPMP-compounds were prepared from a common intermediate and applied to syntheses of novel compounds (e.g. 8-azaguanine derivatives).

引用

页码：695 / 702

页数：8

共 22 条

[1] GENERAL-METHOD OF PREPARATION OF N-[(S)-(3-HYDROXY-2-PHOSPHONOMETHOXYPROPYL)] DERIVATIVES OF HETEROCYCLIC BASES
ALEXANDER, P
HOLY, A
[J]. COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1993, 58 (05) : 1151 - 1163
[2] DIFFERENTIAL ANTIHERPESVIRUS AND ANTIRETROVIRUS EFFECTS OF THE (S) AND (R) ENANTIOMERS OF ACYCLIC NUCLEOSIDE PHOSPHONATES - POTENT AND SELECTIVE INVITRO AND INVIVO ANTIRETROVIRUS ACTIVITIES OF (R)-9-(2-PHOSPHONOMETHOXYPROPYL)-2,6-DIAMINOPURINE
BALZARINI, J
HOLY, A
JINDRICH, J
NAESENS, L
SNOECK, R
SCHOLS, D
DECLERCQ, E
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (02) : 332 - 338
[3] 9-[(2RS)-3-FLUORO-2-PHOSPHONYLMETHOXYPROPYL] DERIVATIVES OF PURINES - A CLASS OF HIGHLY SELECTIVE ANTIRETROVIRAL AGENTS INVITRO AND INVIVO
BALZARINI, J
HOLY, A
JINDRICH, J
DVORAKOVA, H
HAO, Z
SNOECK, R
HERDEWIJN, P
JOHNS, DG
DECLERCQ, E
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (11) : 4961 - 4965
[4] SYNTHESIS AND ANTIVIRAL ACTIVITY OF THE NUCLEOTIDE ANALOG (S)-1-[3-HYDROXY-2-(PHOSPHONYLMETHOXY)PROPYL]CYTOSINE
BRONSON, JJ
GHAZZOULI, I
HITCHCOCK, MJM
WEBB, RR
MARTIN, JC
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (07) : 1457 - 1463
[5] INHIBITION OF THE GROWTH OF PLASMODIUM-FALCIPARUM AND PLASMODIUM-BERGHEI BY THE DNA-POLYMERASE INHIBITOR HPMPA
DEVRIES, E
STAM, JG
FRANSSEN, FFJ
NIEUWENHUIJS, H
CHAVALITSHEWINKOON, P
DECLERCQ, E
OVERDULVE, JP
VANDERVLIET, PC
[J]. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1991, 47 (01) : 43 - 50
[6] SYNTHESIS AND BIOLOGICAL EFFECTS OF 9-(3-HYDROXY-2-PHOSPHONOMETHOXYPROPYL) DERIVATIVES OF DEAZAPURINE BASES
DVORAKOVA, H
HOLY, A
ALEXANDER, P
[J]. COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1993, 58 (06) : 1403 - 1418
[7] DVORAKOVA H, 1993, COLLECT CZECH CHEM C, V58, P253
[8] DVORAKOVA H, 1990, COLLECT CZECH CHEM C, V55, P113
[9] Franchetti P., 1993, Antiviral Research, V20, P60
[10] HOCKOVA D, 1993, COLLECT CZECH CHEM C, V58, P250

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