CHARACTERIZATION OF A DIURETIC PEPTIDE FROM LOCUSTA-MIGRATORIA

被引：78

作者：

KAY, I ^{[1
]}

WHEELER, CH ^{[1
]}

COAST, GM ^{[1
]}

TOTTY, NF ^{[1
]}

CUSINATO, O ^{[1
]}

PATEL, M ^{[1
]}

GOLDSWORTHY, GJ ^{[1
]}

机构：

[1] LUDWIG INST CANC RES,LONDON W1P 8BT,ENGLAND

来源：

BIOLOGICAL CHEMISTRY HOPPE-SEYLER | 1991年 / 372卷 / 10期

关键词：

DIURETIC PEPTIDE; LOCUSTA-MIGRATORIA; MALPIGHIAN TUBULES; FLUID SECRETION; CORTICOTROPIN RELEASING FACTOR-LIKE PEPTIDES;

D O I：

10.1515/bchm3.1991.372.2.929

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A diuretic peptide Locusta-DP, identified by its ability to increase cyclic AMP production in locust Malpighian tubules in vitro, has been isolated and characterized from whole heads of Locusta migratoria. The purified peptide stimulates fluid secretion by Malpighian tubules maximally in vitro. The primary structure of Locusta-DP was established as a 46 residue amidated peptide: M G M G P S L S I V N P M D V L R Q R L L L E I A R R R L R D A E E Q I K A N K D F L Q Q I-NH2. Locusta-DP has 48% sequence identity with Acheta-DP and 49% identity with Manduca-DH, and provides further evidence for the presence of a family of diuretic peptides in insects.

引用

页码：929 / 934

页数：6

共 22 条

[1]

BROWN BL, 1972, ADV CYCL NUCL RES<D>, V2, P25

[2] FLUID SECRETION BY SINGLE ISOLATED MALPIGHIAN TUBULES OF THE HOUSE CRICKET, ACHETA-DOMESTICUS, AND THEIR RESPONSE TO DIURETIC HORMONE [J].