STEREOCHEMICAL, MECHANISTIC, AND STRUCTURAL FEATURES OF ENZYME-CATALYZED PHOSPHATE MONOESTER HYDROLYZES

被引：58

作者：

GANI, D

WILKIE, J

机构：

来源：

CHEMICAL SOCIETY REVIEWS | 1995年 / 24卷 / 01期

关键词：

D O I：

10.1039/cs9952400055

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Phosphoryl transfer is intimately involved at all levels of cellular control. This short review summarizes and highlights our understanding of the chemistry of phosphate monoester hydrolyses in a wide range of different enzymic systems. The article draws attention to the similarities and differences in the diverse array of mechanisms that are employed by Nature in mediating phosphate ester hydrolysis and identifies trends that are related to the substrate specificity of phosphatases.

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页码：55 / 63

页数：9

相关论文

共 36 条

[1] ROLE OF MAGNESIUM IN ESCHERICHIA-COLI ALKALINE-PHOSPHATASE [J].

ANDERSON, RA ;

BOSRON, WF ;

KENNEDY, FS ;

VALLEE, BL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (08) :2989-2993

[2] INOSITOL DEPENDENT PHOSPHATE-OXYGEN LIGAND-EXCHANGE CATALYZED BY INOSITOL MONOPHOSPHATASE [J].

BAKER, GR ;

GANI, D .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1991, 1 (04) :193-196

[3] DESIGN AND SYNTHESIS OF 6-ALPHA-SUBSTITUTED 2-BETA,4-ALPHA-DIHYDROXY-1-BETA-PHOSPHORYLOXYCYCLOHEXANES, POTENT INHIBITORS OF INOSITOL MONOPHOSPHATASE [J].

BAKER, R ;

CARRICK, C ;

LEESON, PD ;

LENNON, IC ;

LIVERTON, NJ .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1991, (05) :298-300

[4] CRYSTAL-STRUCTURE OF HUMAN PROTEIN-TYROSINE-PHOSPHATASE 1B [J].

BARFORD, D ;

FLINT, AJ ;

TONKS, NK .

SCIENCE, 1994, 263 (5152) :1397-1404

[5] STRUCTURE OF INOSITOL MONOPHOSPHATASE, THE PUTATIVE TARGET OF LITHIUM-THERAPY [J].

BONE, R ;

SPRINGER, JP ;

ATACK, JR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) :10031-10035

[6]

BRUICE TC, 1966, BIOORG MECH, V2, P1

[7]

BUCHWALD SL, 1984, J BIOL CHEM, V259, P2208

[8] STEREOCHEMICAL EVIDENCE FOR PSEUDOROTATION IN THE REACTION OF A PHOSPHORIC MONOESTER [J].

BUCHWALD, SL ;

PLIURA, DH ;

KNOWLES, JR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (17) :4916-4922

[9] 1002 PROTEIN PHOSPHATASES [J].

CHARBONNEAU, H ;

TONKS, NK .

ANNUAL REVIEW OF CELL BIOLOGY, 1992, 8 :463-493

[10] THE ROLE OF CYS12, CYS17 AND ARG18 IN THE CATALYTIC MECHANISM OF LOW-MR CYTOSOLIC PHOSPHOTYROSINE PROTEIN PHOSPHATASE [J].

CIRRI, P ;

CHIARUGI, P ;

CAMICI, G ;

MANAO, G ;

RAUGEI, G ;

CAPPUGI, G ;

RAMPONI, G .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1993, 214 (03) :647-657

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