DNA PATTERNS OF HELICOBACTER-PYLORI ISOLATED FROM GASTRIC ANTRUM, BODY, AND DUODENUM

被引：81

作者：

PREWETT, EJ

BICKLEY, J

OWEN, RJ

POUNDER, RE

机构：

[1] UNIV LONDON,ROYAL FREE HOSP,SCH MED,ROWLAND HILL ST,LONDON NW3 2PF,ENGLAND

[2] CENT PUBL HLTH LAB,NATL COLLECT TYPE CULTURES,LONDON NW9 5HT,ENGLAND

来源：

GASTROENTEROLOGY | 1992年 / 102卷 / 03期

关键词：

D O I：

10.1016/0016-5085(92)90165-U

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Biopsy specimens for culture of Helicobacter pylori were obtained from two different sites in the antrum, gastric body, and duodenal cap in 20 patients during endoscopic investigation of dyspepsia. H. pylori was identified in 64 isolates obtained from 15 of the 20 patients. Analysis of chromosomal DNA from these isolates of H. pylori showed that 13 of 15 patients harbored a single strain of H. pylori throughout their stomach and duodenum. Two differing H. pylori types were found in two patients. Unique DNA patterns were shown in each of the 15 patients. The genetic heterogeneity of H. pylori is unexplained but it could be of considerable value for epidemiological studies. © 1992.

引用

页码：829 / 833

页数：5

共 22 条

[11] USE OF DNA RESTRICTION ENDONUCLEASE DIGEST AND RIBOSOMAL-RNA GENE PROBE PATTERNS TO FINGERPRINT HELICOBACTER-PYLORI AND HELICOBACTER-MUSTELAE ISOLATED FROM HUMAN AND ANIMAL HOSTS [J].