IMMUNOHISTOCHEMICAL DETECTION OF BCL-2 PROTEIN IN LIVER-LESIONS - BCL-2 PROTEIN IS EXPRESSED IN HEPATOCELLULAR CARCINOMAS BUT NOT IN LIVER-CELL DYSPLASIA

被引：60

作者：

ZHAO, M

ZHANG, NX

ECONOMOU, M

BLAHA, I

LAISSUE, JA

ZIMMERMANN, A

机构：

[1] UNIV BERN,INST PATHOL,CH-3010 BERN,SWITZERLAND

[2] TIANJIN MED COLL,DEPT PATHOL,TIANJIN,PEOPLES R CHINA

来源：

HISTOPATHOLOGY | 1994年 / 25卷 / 03期

关键词：

BCL-2; HEPATOCELLULAR CARCINOMA; LIVER CELL DYSPLASIA;

D O I：

10.1111/j.1365-2559.1994.tb01323.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A proto-oncogene, bcl-2, encodes a protein that inhibits programmed cell death (apoptosis) and may play a role in cell and tissue differentiation. As bcl-2 appears to be involved in the turn-over of stem or precursor cells, it is thought to be operational in carcinogenesis pathways. However, apart from certain lymphomas, only limited data are available on the frequency of its expression in solid tumors. Immunohistochemical analysis with an antibody specific for bcl-2 protein was used to detect the protein in hepatocellular carcinomas and in one of the putative precursor lesions, liver cell dysplasia. We detected bcl-2 protein in 5 of 37 hepatocellular carcinomas. Immunoreactivity was not related to type, grade, or extent of PCNA staining of the tumours. No bcl-2 protein staining was observed in three types of liver cell dysplasia. Thus, bcl-2 is abnormally expressed in some hepatocellular carcinomas but not in potential tumour precursor cells.

引用

页码：237 / 245

页数：9

共 55 条

[11]

COLTRERA MD, 1993, APPL IMMUNOHISTO M M, V1, P193

[12]

CRAWFORD JM, 1990, SEMIN DIAGN PATHOL, V7, P115

[13]

EDMONSON HA, 1954, CANCER, V7, P465

[14]

ELLIS RE, 1991, ANNU REV CELL BIOL, V7, P663, DOI 10.1146/annurev.cb.07.110191.003311

[15]

FRANCIS SE, 1992, J PATHOL, V166, P418

[16] CYCLIN PCNA IMMUNOSTAINING AS AN ALTERNATIVE TO TRITIATED-THYMIDINE PULSE LABELING FOR MARKING S-PHASE CELLS IN PARAFFIN SECTIONS FROM ANIMAL AND HUMAN-TISSUES [J].

GALAND, P ;

DEGRAEF, C .

CELL AND TISSUE KINETICS, 1989, 22 (05) :383-392

[17]

GARCIA RL, 1989, AM J PATHOL, V134, P733

[18]

GELB AB, 1992, AM J PATHOL, V141, P453

[19]

GERMAIN L, 1988, CANCER RES, V48, P4909

[20]

GIANNINI A, 1987, HEPATO-GASTROENTEROL, V34, P95

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