REDUCTIVE CLEAVAGE OF THE RIBOSE MOIETY IN PURINE NUCLEOSIDES USING DIISOBUTYLALUMINUM HYDRIDE - A NEW METHOD FOR THE PREPARATION OF ACYCLONUCLEOSIDES

被引：16

作者：

KITADE, Y

HIROTA, K

MAKI, Y

机构：

[1] Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, Gifu, 502

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 30期

关键词：

D O I：

10.1016/S0040-4039(00)74102-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of purine nucleosides, such as 2',3'-O-isopropylideneinosine 1a and 2',3'-O-isopropylideneadenosine 1c, with diisobutylaluminum hydride in dry tetrahydrofuran resulted in the reductive cleavage of the ribose moiety at the anomeric position to give the corresponding 9-(2',3'-O-isopropylideneribityl)purines 2a, c in good yields.

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收藏

页码：4835 / 4836

页数：2

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