Autophagy-independent effects of autophagy-related-5 (Atg5) on exosome production and metastasis

被引：20

作者：

Guo, Huishan ^{[1
,2
]}

Sadoul, Remy ^{[3
,4
]}

Gibbings, Derrick ^{[1
,2
]}

机构：

[1] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON, Canada

[2] Univ Ottawa, Ottawa Inst Syst Biol, Ottawa, ON, Canada

[3] Univ Grenoble Alpes, Grenoble Inst Neurosci, F-38706 Grenoble, France

[4] INSERM, Grenoble, France

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2018年 / 5卷 / 03期

关键词：

autophagy; exosomes; V1V0-ATPase; acidification; metastasis; biology of malignant cells; mechanisms of oncogenesis and tumor progression;

D O I：

10.1080/23723556.2018.1445941

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Autophagy-related-5 (Atg5) and Autophagy-related-16-Like-1 (Atg16L1) canonically participate in autophagy. Recent research demonstrates that apart from this, they also control production of extracellular vesicles called exosomes by regulating acidification of late endosomes. Atg5-mediated exosome production increased migration and metastasis of breast cancer cells suggesting exosomes may perform some functions ascribed to autophagy.

引用

页数：3

共 10 条

[1]

Mammalian Autophagy: How Does It Work? [J].

Bento, Carla F. ;

Renna, Maurizio ;

Ghislat, Ghita ;

Puri, Claudia ;

Ashkenazi, Avraham ;

Vicinanza, Mariella ;

Menzies, Fiona M. ;

Rubinsztein, David C. .

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 85, 2016, 85 :685-713

[2]

Hidden Behind Autophagy: The Unconventional Roles of ATG Proteins [J].

Bestebroer, Jovanka ;

V'kovski, Philip ;

Mauthe, Mario ;

Reggiori, Fulvio .

TRAFFIC, 2013, 14 (10) :1029-1041

[3]

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles [J].

Colombo, Marina ;

Raposo, Graca ;

Thery, Clotilde .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30, 2014, 30 :255-289

[4]

Recent Insights into the Structure, Regulation, and Function of the V-ATPases [J].

Cotter, Kristina ;

Stransky, Laura ;

McGuire, Christina ;

Forgac, Michael .

TRENDS IN BIOCHEMICAL SCIENCES, 2015, 40 (10) :611-622

[5]

Autophagy in malignant transformation and cancer progression [J].

Galluzzi, Lorenzo ;

Pietrocola, Federico ;

Bravo-San Pedro, Jose Manuel ;

Amaravadi, Ravi K. ;

Baehrecke, Eric H. ;

Cecconi, Francesco ;

Codogno, Patrice ;

Debnath, Jayanta ;

Gewirtz, David A. ;

Karantza, Vassiliki ;

Kimmelman, Alec ;

Kumar, Sharad ;

Levine, Beth ;

Maiuri, Maria Chiara ;

Martin, Seamus J. ;

Penninger, Josef ;

Piacentini, Mauro ;

Rubinsztein, David C. ;

Simon, Hans-Uwe ;

Simonsen, Anne ;

Thorburn, Andrew M. ;

Velasco, Guillermo ;

Ryan, Kevin M. ;

Kroemer, Guido .

EMBO JOURNAL, 2015, 34 (07) :856-880

[6]

Atg5 Disassociates the V1V0-ATPase to Promote Exosome Production and Tumor Metastasis Independent of Canonical Macroautophagy [J].

Guo, Huishan ;

Chitiprolu, Maneka ;

Roncevic, Luc ;

Javalet, Charlotte ;

Hemming, Fiona J. ;

Trung, My Tran ;

Meng, Lingrui ;

Latreille, Elyse ;

de Souza, Christiano Tanese ;

McCulloch, Danielle ;

Baldwin, R. Mitchell ;

Auer, Rebecca ;

Cote, Jocelyn ;

Russell, Ryan Charles ;

Sadoul, Remy ;

Gibbings, Derrick .

DEVELOPMENTAL CELL, 2017, 43 (06) :716-+

[7]

Tumour exosome integrins determine organotropic metastasis [J].

Hoshino, Ayuko ;

Costa-Silva, Bruno ;

Shen, Tang-Long ;

Rodrigues, Goncalo ;

Hashimoto, Ayako ;

Mark, Milica Tesic ;

Molina, Henrik ;

Kohsaka, Shinji ;

Di Giannatale, Angela ;

Ceder, Sophia ;

Singh, Swarnima ;

Williams, Caitlin ;

Soplop, Nadine ;

Uryu, Kunihiro ;

Pharmer, Lindsay ;

King, Tari ;

Bojmar, Linda ;

Davies, Alexander E. ;

Ararso, Yonathan ;

Zhang, Tuo ;

Zhang, Haiying ;

Hernandez, Jonathan ;

Weiss, Joshua M. ;

Dumont-Cole, Vanessa D. ;

Kramer, Kimberly ;

Wexler, Leonard H. ;

Narendran, Aru ;

Schwartz, Gary K. ;

Healey, John H. ;

Sandstrom, Per ;

Labori, Knut Jorgen ;

Kure, Elin H. ;

Grandgenett, Paul M. ;

Hollingsworth, Michael A. ;

de Sousa, Maria ;

Kaur, Sukhwinder ;

Jain, Maneesh ;

Mallya, Kavita ;

Batra, Surinder K. ;

Jarnagin, William R. ;

Brady, Mary S. ;

Fodstad, Oystein ;

Muller, Volkmar ;

Pantel, Klaus ;

Minn, Andy J. ;

Bissell, Mina J. ;

Garcia, Benjamin A. ;

Kang, Yibin ;

Rajasekhar, Vinagolu K. ;

Ghajar, Cyrus M. .

NATURE, 2015, 527 (7578) :329-+

[8]

Autophagy and Tumor Metabolism [J].

Kimmelman, Alec C. ;

White, Eileen .

CELL METABOLISM, 2017, 25 (05) :1037-1043

[9]

Autophagy in cancer metastasis [J].

Mowers, E. E. ;

Sharifi, M. N. ;

Macleod, K. F. .

ONCOGENE, 2017, 36 (12) :1619-1630

[10]

LC3/GABARAP family proteins: autophagy-(un) related functions [J].

Schaaf, Marco B. E. ;

Keulers, Tom G. ;

Vooijs, Marc A. ;

Rouschop, Kasper M. A. .

FASEB JOURNAL, 2016, 30 (12) :3961-3978

← 1 →