INCREASED TYPE-I AND TYPE-III COLLAGEN AND TRANSFORMING GROWTH-FACTOR-BETA-1 MESSENGER-RNA AND PROTEIN IN HYPERTROPHIC BURN SCAR

被引：136

作者：

ZHANG, K

GARNER, W

COHEN, L

RODRIGUEZ, J

PHAN, S

机构：

[1] UNIV MICHIGAN HOSP,MED CTR,PLAST & RECONSTRUCT SURG SECT,ANN ARBOR,MI 48109

[2] UNIV MICHIGAN HOSP,MED CTR,DEPT PATHOL,ANN ARBOR,MI 48109

[3] UNIV MICHIGAN HOSP,MED CTR,DEPT SURG,ANN ARBOR,MI 48109

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 1995年 / 104卷 / 05期

关键词：

FIBROSIS; DERMAL FIBROBLASTS; CYTOKINE;

D O I：

10.1111/1523-1747.ep12606979

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Hypertrophic scar is the result of abnormal healing that often follows thermal injury. Hypertrophic scar is characterized by excessive dermal fibrosis and scarring. Five cases of human hypertrophic scar were compared with normal skin using in situ hybridization to localize mRNAs for procollagen types I and III and transforming growth factor-beta 1. Expression of type I procollagen and TGF-beta 1 were also examined with immunohistochemistry. The results demonstrated a significant increase in the expression of mRNA for types I and III procollagen and type I procollagen protein by fibroblasts in hypertrophic scar compared with normal skin. In all cases of hypertrophic scar, significant numbers of cells expressed TGF-beta 1 mRNA or peptide. Neither TGF-beta 1 mRNA nor protein was detected in control tissues. These results suggest a profound increase in production and expression of types I and III collagen mRNA by the fibroblasts in hypertrophic scar. This may result from increased TGF-beta 1 production, through paracrine and autocrine pathways, as have been described for this fibrogenic cytokine.

引用

页码：750 / 754

页数：5

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