MECHANISM OF INTRACELLULAR PROTEIN-TRANSPORT

被引：2041

作者：

ROTHMAN, JE

机构：

[1] Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021

来源：

NATURE | 1994年 / 372卷 / 6501期

关键词：

D O I：

10.1038/372055a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent advances have uncovered the general protein apparatus used by all eukaryotes for intracellular transport, including secretion and endocytosis, and for triggered exocytosis of hormones and neurotransmitters. Membranes are shaped into vesicles by cytoplasmic coats which then dissociate upon GTP hydrolysis. Both vesicles and their acceptor membranes carry targeting. proteins which interact specifically to initiate docking. A general apparatus then assembles at the docking site and fuses the vesicle with its target.

引用

页码：55 / 63

页数：9

共 126 条

[121] N-ETHYLMALEIMIDE-SENSITIVE FUSION PROTEIN - A TRIMERIC ATPASE WHOSE HYDROLYSIS OF ATP IS REQUIRED FOR MEMBRANE-FUSION [J].