INHIBITORS OF THE ADENOVIRUS TYPE-2 PROTEINASE BASED ON SUBSTRATE-LIKE TETRAPEPTIDE NITRILES

被引：15

作者：

CORNISH, JA

MURRAY, H

KEMP, GD

GANI, D

机构：

[1] UNIV ST ANDREWS, SCH CHEM, ST ANDREWS KY16 9ST, FIFE, SCOTLAND

[2] UNIV ST ANDREWS, SCH BIOL & MED SCI, DIV BIOCHEM & MOLEC BIOL, ST ANDREWS KY16 9AL, FIFE, SCOTLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 01期

关键词：

D O I：

10.1016/0960-894X(94)00452-L

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Tetrapeptides containing the substrate derived P-4-P-1 residues Leu-Ala-Gly-Gly and C-terminal ester, acid, amide, nitrile and dimethylacetal functionalities were synthesised and tested as inhibitors of the adenovirus type 2 proteinase. The acids and amides did not act as inhibitors and the dimethyl acetals and the nitriles served as moderate and good reversible inhibitors respectively.

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页码：25 / 30

页数：6

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