MATURATIONAL CHANGES IN CEREBRAL FUNCTION IN INFANTS DETERMINED BY F-18 DG POSITRON EMISSION TOMOGRAPHY

被引：475

作者：

CHUGANI, HT

PHELPS, ME

机构：

[1] UNIV CALIF LOS ANGELES, SCH MED, DEPT PEDIAT, LOS ANGELES, CA 90024 USA

[2] UNIV CALIF LOS ANGELES, SCH MED, DIV NUCL MED & BIOPHYS, LOS ANGELES, CA 90024 USA

来源：

SCIENCE | 1986年 / 231卷 / 4740期

关键词：

D O I：

10.1126/science.3945811

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

2-Deoxy-2[18F]fluoro-D-glucose positron emission tomography performed in human infants during development revealed progessive changes in local cerebral glucose utilization. In infants 5 weeks of age and younger, glucose utilization was highest in the sensorimotor cortex, thalamus, midbrain-brainstem, and cerebellar vermis. By 3 months, glucose metabolic activity had increased in the parietal, temporal, and occipital cortices and the basal ganglia, with subsequent increases in frontal and various association regions occurring by 8 months. These functional changes measured with positron emission tomography are in agreement with behavioral, neurophysiological, and anatomical alterations known to occur during infant development.

引用

页码：840 / 843

页数：4

共 47 条

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