COMPARATIVE MAPPING OF THE ACTIN-BINDING PROTEIN-280 GENES IN HUMAN AND MOUSE

被引：19

作者：

GARIBOLDI, M

MAESTRINI, E

CANZIAN, F

MANENTI, G

DEGREGORIO, L

RIVELLA, S

CHATTERJEE, A

HERMAN, GE

ARCHIDIACONO, N

ANTONACCI, R

PIEROTTI, MA

DRAGANI, TA

TONIOLO, D

机构：

[1] IST NAZL TUMORI,DIV EXPTL ONCOL A,I-20133 MILAN,ITALY

[2] CNR,IST GENET BIOCHIM & EVOLUZIONIST,I-27100 PAVIA,ITALY

[3] UNIV BARI,IST GENET,BARI,ITALY

[4] BAYLOR COLL MED,INST MOLEC GENET,HOUSTON,TX 77030

来源：

GENOMICS | 1994年 / 21卷 / 02期

关键词：

D O I：

10.1006/geno.1994.1288

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two genes encode actin-binding protein 280 isoforms. ABP-280 or filamin (FLN1) is present in the cytoskeleton of many cell types, whereas expression of FLN2 is limited to skeletal muscle and heart. FLN1 maps to human chromosome Xq28, and, by physical mapping in YAC clones, we have mapped the homologous murine locus (Fln1) to mouse chromosome X, in a region of syntenic homology with human chromosome X. We mapped FLN2 to human chromosome 7q32-q35 by analysis of somatic cell hybrids containing portions of chromosome 7, and, by using a mapping panel from an interspecific murine cross, we mapped the corresponding murine locus (Fln2) to murine chromosome 6 in a region homologous to human chromosome 7. (C) 1994 Academic Press, Inc.

引用

页码：428 / 430

页数：3

共 21 条

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