CHARACTERIZATION OF THE SERUM ANTIBODY-RESPONSE INDUCED BY HAEMOPHILUS-INFLUENZAE TYPE-B TETANUS PROTEIN-CONJUGATE VACCINE IN INFANTS RECEIVING A DTP-COMBINED VACCINE FROM 2 MONTHS OF AGE

被引：13

作者：

BARRA, A

DAGAN, R

PREUDHOMME, JL

BAJART, A

DANVE, B

FRITZELL, B

机构：

[1] UNIV HOSP POITIERS,IMMUNOL & IMMUNOPATHOL,CNRS,URA 1172,BP 577,F-86021 POITIERS,FRANCE

[2] BEN GOURION UNIV NEGEV,PAEDIAT INFECT DIS UNIT,BEER SHEVA,ISRAEL

[3] PASTEUR MERIEUX SERUMS & VACCINS,F-69280 MARCY LETOILE,FRANCE

[4] PASTEUR MERIEUX SERUMS & VACCINS,F-92430 MARNES COQUETTE,FRANCE

来源：

VACCINE | 1993年 / 11卷 / 10期

关键词：

HAEMOPHILUS-INFLUENZAE TYPE-B; INFANTS; SERUM ANTIBODY RESPONSE; DTP VACCINE;

D O I：

10.1016/0264-410X(93)90124-G

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The serum antibody response induced by Haemophilus influenzae type b capsular polysaccharide (CPS)-tetanus protein conjugate vaccine combined to DTP vaccine was characterized in infants receiving three injections from 2 months of age. Sixty-five per cent and 94% of infants had anti-CPS antibody levels greater-than-or-equal-to 1 mug ml-1 after the second and third dose, respectively. The antibody response was mostly made up of IgG with a marked IgG1 predominance. Significant rises in bactericidal and in complement-mediated opsonic activities were observed after immunization. These data clearly show that this vaccine can be successfully administered in one syringe together with DTP vaccine during the regular infant immunization programme.

引用

页码：1003 / 1006

页数：4

共 29 条

[21] THE EFFICACY IN NAVAJO INFANTS OF A CONJUGATE VACCINE CONSISTING OF HAEMOPHILUS-INFLUENZAE TYPE-B POLYSACCHARIDE AND NEISSERIA-MENINGITIDIS OUTER-MEMBRANE PROTEIN COMPLEX [J].