VALUE OF URINARY ENDOTHELIN-1 IN PATIENTS WITH PRIMARY VESICOURETERAL REFLUX

被引：9

作者：

KOMEYAMA, T ^{[1
]}

TAKEDA, M ^{[1
]}

KATAYAMA, Y ^{[1
]}

TSUTSUI, T ^{[1
]}

MIZUSAWA, T ^{[1
]}

TAKAHASHI, H ^{[1
]}

HATANO, A ^{[1
]}

OBARA, K ^{[1
]}

SATO, S ^{[1
]}

机构：

[1] NIIGATA UNIV,SCH MED,DEPT UROL,ASAHI MACHI 1,NIIGATA 951,JAPAN

来源：

NEPHRON | 1993年 / 65卷 / 04期

关键词：

URINARY ENDOTHELIN-1; VESICOURETERAL REFLUX; N-ACETYL-BETA-D-GLUCOSAMINIDASE; BETA-2-MICROGLOBULIN; MICROALBUMIN;

D O I：

10.1159/000187560

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

By using a radioimmunoassay specific for endothelin-1 (ET-1), we measured urinary excretion of ET-1-like immunoreactivity (LI) in 63 spot urine samples of 48 patients with primary vesicoureteral reflux (VUR). And also, urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG), beta2-microglobulin (beta2-MG), microalbumin (Alb) and creatinine (Cr) were measured. There was no significant correlation in any of the pairs ET-1 and NAG, ET-1 and beta2-MG, and ET-1 and Alb. Comparing the grade of reflux according to the International Classification with urinary ET-1, urinary ET-1/Cr levels in patients with grade 2, 3 and 4 VUR were higher than normal, and the ratio of more than normal urinary ET-1/Cr increased in proportion to the grade of reflux, but it conversely decreased in grade 5. In conclusion, urinary ET-1 may be an indicator of renal tubular injury in patients with primary VUR, and its meaning may be different from conventional urinary parameters.

引用

页码：537 / 540

页数：4

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