INTERACTION BETWEEN ERBB- RECEPTORS AND HEREGULIN IN BREAST-CANCER TUMOR PROGRESSION AND DRUG-RESISTANCE

被引：58

作者：

LUPU, R

CARDILLO, M

HARRIS, L

HIJAZI, M

ROSENBERG, K

机构：

[1] Vincent T. Lombardi Cancer Res. Ctr., Georgetown Univ., School of Medicine and Lombardi Cancer Res. Center, Washington, DC 20007

来源：

SEMINARS IN CANCER BIOLOGY | 1995年 / 6卷 / 03期

关键词：

HEREGULIN; BREAST CANCER; GROWTH FACTOR RECEPTORS; ERBB; ONCOGENE;

D O I：

10.1006/scbi.1995.0016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The type 1 growth factor receptor family is increasingly recognized as important in the development and maintenance of breast cancer The family currently consists of four closely related members: the epidermal growth factor receptor (ECF-R/erbB-1), erbB-2, erbB-3 and erbB-4. Putative ligands which bind directly to or indirectly activate erbB-2/3/4 have been. characterized recently. This still growing family of EGF-related growth factors includes gp30, its homolog heregulin (HRG) the rat homolog neu differentiation factor (NDF) glial growth factors (GLIA) ARIA and a 50 kDa factor from COLO 16 cells. The understanding of the function, biology and interactions of these growth factor receptors and their ligands will have far-reaching implications for the prognosis and treatment of breast cancer This review focuses on. advances and future directions for further investigations intended to clarify the mechanism and significance of erbB/ligand interactions in breast cancer.

引用

页码：135 / 145

页数：11

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