DIFFERENT OXYGEN-TRANSPORT PATTERNS IN PATIENTS WITH ADULT RESPIRATORY-DISTRESS SYNDROME TREATED WITH POSITIVE END-EXPIRATORY PRESSURE

被引：3

作者：

DUBIN, A ^{[1
]}

ESTENSSORO, E ^{[1
]}

SILVA, C ^{[1
]}

TOLEDO, P ^{[1
]}

ARN, HG ^{[1
]}

MODAY, M ^{[1
]}

ESPERANZA, M ^{[1
]}

PAZ, T ^{[1
]}

MAFFEI, R ^{[1
]}

LAPORTE, M ^{[1
]}

机构：

[1] HOSP INTERZONAL AGUDOS,SERV TERAPIA INTENS,LA PLATA,BUENOS AIRES,ARGENTINA

来源：

JOURNAL OF CRITICAL CARE | 1990年 / 5卷 / 02期

关键词：

D O I：

10.1016/0883-9441(90)90055-E

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

To test the hypothesis that different oxygen transport patterns reported in adult respiratory distress syndrome (ARDS) could be due to the presence of sepsis, we prospectively studied 28 mechanically ventilated patients with ARDS who received positive end-expiratory pressure (PEEP) at 0, 5, 10, and 15 cm H2O. Nonseptic patients showed a strong correlation between oxygen delivery index (DO2I) and mixed venous oxygen saturation (SvO2) (r = .77, P < .001) and DO2I and oxygen extraction ratio (O2ER) (r = -.87, P < .001), and a correlation between DO2I and oxygen consumption index (VO2I) best described by third-degree polynomial fit (r = .86) which allowed the description of a critical DO2 point of 293 mL/min/m2. Septic patients showed no consistent relationship between DO2I and SvO2 (r = .21, P = NS), and DO2I and O2ER (r = -.21, P = NS), but DO2I and VO2I correlated linearly (r = .72, P < .001) in what has been described as pathologic dependence of VO2 on DO2. We suggest that sepsis seems to be the determinant of this abnormal relationship between supply and utilization of oxygen in our ARDS patients treated with PEEP. © 1990.

引用

页码：101 / 107

页数：7

共 56 条

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