AUTOLOGOUS MARROW RECONSTITUTIONS IN SEVERE APLASTIC-ANEMIA AFTER ALG PRETREATMENT AND HL-A SEMI-INCOMPATIBLE BONE-MARROW CELL TRANSFUSION

Three consecutive patients considered to have end-stage acquired aplastic anemia were given 100-160 mg/kg antilymphocyte globulin (ALG) i.v. followed by an infusion of 2-3.8 .times. 108 nucleated marrow cells/kg i.v. from HL-A one haplotype-identical, MLC [mixed lymphocyte culture]-positive family donors. All patients showed autologous marrow reconstitutions lasting now 2-3 1/2 yr. No clear-cut evidence of marrow engraftment could be established and no graft-vs-host disease was seen. These patients probably had some normal pluripotent hemopoetic stem cells which were capable of endoreduplication and of going into cycle after ALG conditioning and allogeneic marrow transfusion.