AUTOLOGOUS MARROW RECONSTITUTIONS IN SEVERE APLASTIC-ANEMIA AFTER ALG PRETREATMENT AND HL-A SEMI-INCOMPATIBLE BONE-MARROW CELL TRANSFUSION

被引：36

作者：

JEANNET, M

SPECK, B

RUBINSTEIN, A

PELET, B

WYSS, M

KUMMER, H

机构：

[1] UNIV HOSP GENEVA, DEPT PAEDIAT, GENEVA, SWITZERLAND

[2] UNIV HOSP GENEVA, DIV IMMUNOL & ALLERGY, TRANSPLANTATION IMMUNOL UNIT, GENEVA, SWITZERLAND

[3] UNIV HOSP BASEL, DIV HAEMATOL, BASEL, SWITZERLAND

[4] UNIV HOSP BERN, DEPT PAEDIAT, BERN, SWITZERLAND

来源：

ACTA HAEMATOLOGICA | 1976年 / 55卷 / 03期

关键词：

D O I：

10.1159/000208005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Three consecutive patients considered to have end-stage acquired aplastic anemia were given 100-160 mg/kg antilymphocyte globulin (ALG) i.v. followed by an infusion of 2-3.8 .times. 108 nucleated marrow cells/kg i.v. from HL-A one haplotype-identical, MLC [mixed lymphocyte culture]-positive family donors. All patients showed autologous marrow reconstitutions lasting now 2-3 1/2 yr. No clear-cut evidence of marrow engraftment could be established and no graft-vs-host disease was seen. These patients probably had some normal pluripotent hemopoetic stem cells which were capable of endoreduplication and of going into cycle after ALG conditioning and allogeneic marrow transfusion.

引用

页码：129 / 139

页数：11