THE EFFECT OF 5-HYDROXYEICOSATETRAENOIC ACID ON THE PROLIFERATION OF GRANULOCYTE PROGENITORS AND EMBRYONIC FIBROBLASTS OF THE CHICK

被引：17

作者：

DODGE, W

THOMAS, M

机构：

[1] WAKE FOREST UNIV, BOWMAN GRAY SCH MED, DEPT MED, WINSTON SALEM, NC 27103 USA

[2] WAKE FOREST UNIV, BOWMAN GRAY SCH MED, DEPT BIOCHEM, WINSTON SALEM, NC 27103 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1985年 / 131卷 / 02期

关键词：

D O I：

10.1016/0006-291X(85)91299-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The clonal proliferation of chicken granulocytic progenitors was inhibited 5-20 fold by the eicosanoid, 5-HETE, at 1.0 .mu.M. Inhibition occurred at the lowest concentration measured (0.12 .mu.M). This compound at 0.6 to 1.0 .mu.M also inhibited the clonal proliferation of chick embryo fibroblasts by as much as 10-fold.

引用

页码：731 / 735

页数：5

共 19 条

[1] LIPOXYGENASE-DERIVED PRODUCTS OF ARACHIDONIC-ACID MEDIATE STIMULATION OF HEXOSE UPTAKE IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES [J].