GLOMERULAR ULTRAFILTRATION IN RABBITS WITH SUPERFICIAL GLOMERULI

被引:18
作者
DENTON, KM [1 ]
ANDERSON, WP [1 ]
机构
[1] BAKER MED RES INST,COMMERCIAL RD,PRAHRAN,VIC 3181,AUSTRALIA
来源
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 1991年 / 419卷 / 3-4期
关键词
GLOMERULAR CAPILLARY PRESSURE; GLOMERULAR ULTRAFILTRATION COEFFICIENT; SNGFR;
D O I
10.1007/BF00371101
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The determinants of glomerular ulrafiltration in superficial glomeruli of a strain of English cross-breed rabbits have been studied using micropuncture techniques. Mean arterial blood pressure in the anaesthetised rabbits was 70 +/- 2 mmHg. The glomerular filtration rate in the kidney prepared for micropuncture was 4.4 +/- 0.4 ml/min, the filtration fraction was 22 +/- 1% and renal blood flow was 33 +/- 3 ml/min, and these values were comparable to values in conscious rabbits. Glomerular capillary pressure (P(gc)) averaged 31 +/- 1 mmHg, the single-nephron glomerular filtration rate (SNGFR) averaged 25 +/- 2 nl/min, and the mean ultrafiltration pressure (calculated using the whole-kidney filtration fraction) averaged 7 +/- 1 mmHg. A net positive pressure at the efferent end of the glomerular capillaries (4.4 +/- 0.9 mmHg) indicated that a state of filtration pressure disequilibrium existed, under the experimental conditions of this study, in rabbit glomeruli. The calculated glomerular ultrafiltration coefficient (K(f)) was 0.08 +/- 0.01 nl s-1 mmHg-1. Thus, compared to the Munich-Wistar rat, SNGFR is lower in the rabbit. This reflects the substantially lower glomerular ultrafiltration pressure in the rabbit, although this was offset partially by a higher K(f).
引用
收藏
页码:235 / 242
页数:8
相关论文
共 33 条
[31]  
RHODE R, 1968, PFLUGERS ARCH, V302, P219
[32]   INDUCTION, PREVENTION AND MECHANISMS OF CONTRAST MEDIA-INDUCED ACUTE RENAL-FAILURE [J].
VARI, RC ;
NATARAJAN, LA ;
WHITESCARVER, SA ;
JACKSON, BA ;
OTT, CE .
KIDNEY INTERNATIONAL, 1988, 33 (03) :699-707
[33]   ELECTROLYTE HANDLING BY THE SUPERFICIAL NEPHRON OF THE RABBIT [J].
WONG, NLM ;
WHITING, SJ ;
MIZGALA, CL ;
QUAMME, GA .
AMERICAN JOURNAL OF PHYSIOLOGY, 1986, 250 (04) :F590-F595