3'-DEOXY-3'-(VINYLSULPHONYL)THYMIDINE - A NEW REACTIVE ANALOG OF AZT - ITS SYNTHESIS AND REACTIVITIES TOWARDS VARIOUS NUCLEOPHILES

被引：19

作者：

BERA, S

SAKTHIVEL, K

PATHAK, T

LANGLEY, GJ

机构：

[1] NATL CHEM LAB,DIV ORGAN CHEM SYNTH,POONA 411008,MAHARASHTRA,INDIA

[2] UNIV SOUTHAMPTON,DEPT CHEM,SOUTHAMPTON SO9 5NH,HANTS,ENGLAND

来源：

TETRAHEDRON | 1995年 / 51卷 / 28期

关键词：

D O I：

10.1016/0040-4020(95)00403-U

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A reactive triatomic analogue of AZT, 3'-deoxy-3'-(vinylsulphonyl)thymidine has been synthesised from easily accessible starting material. The vinyl-sulphone nucleoside was reacted with a variety of nucleophiles to generate new classes of modified nucleosides where the functional soups were attached to the C-3' of a nucleoside through flexible ethyl sulphone spacer.

引用

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页码：7857 / 7866

页数：10

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