EFFECT OF ILLUMINATED NIFEDIPINE, A POTENT ANTIOXIDANT, ON INTESTINAL AND VASCULAR SMOOTH MUSCLES

被引：10

作者：

BAUER, V ^{[1
]}

REKALOV, VV ^{[1
]}

JURANEK, I ^{[1
]}

GERGEL, D ^{[1
]}

BOHOV, P ^{[1
]}

机构：

[1] UKRAINIAN ACAD SCI,AA BOGOMOLETS PHYSIOL INST,KIEV 252160,UKRAINE

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1995年 / 115卷 / 06期

关键词：

ILLUMINATED NIFEDIPINE; SMOOTH MUSCLE; CALCIUM CURRENT; ANTIOXIDANT;

D O I：

10.1111/j.1476-5381.1995.tb15890.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 The effects of nifedipine (Nif) and its illuminated nitroso product nitrosopine (NTP) were investigated on lipid peroxidation, KCI elevated smooth muscle tension, and ionic currents of single smooth muscle cells. 2 Illumination of Nif at 400-700 nm within 24-48 h changed it completely to a potent antioxidant, NTP. 3 Nif relaxed the KCl-induced contractions of guinea-pig taenia caeci and rat aorta and reduced the amplitude of the evoked inward Ca2+ current of taenia caeci cells in a concentration-dependent manner. NTP (up to 100 M) was ineffective in this respect. Pretreatment by NTP (10 mu M) did not affect the actions of Nif. 4 The evidence suggests that NTP, generated by day-light illumination from Nif, exerts antioxidant activity but is devoid of voltage-dependent Ca2+ channel (VDC) blocking property and does not interfere with the action of Nif on the smooth muscle cell membrane VDC.

引用

页码：871 / 874

页数：4

共 16 条

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