TROPONIN ISOFORM SWITCHING IN THE DEVELOPING HEART AND ITS FUNCTIONAL CONSEQUENCES

被引：73

作者：

SCHIAFFINO, S

GORZA, L

AUSONI, S

机构：

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 1993年 / 3卷 / 01期

关键词：

D O I：

10.1016/1050-1738(93)90022-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The subunits of the troponin complex-troponin C, troponin T, and troponin I-are responsible for the Ca2+-dependent regulation of contractile activity in heart and skeletal muscle. Distinct troponin T and I isoforms, generated by different genes or by alternative splicing from the same gene, are expressed during cardiac development. Troponin switching affects the Ca2+ sensitivity of the contractile system and may account for the greater resistance to hypoxia and acidosis, and the impaired responsiveness to adrenergic stimulation of the fetal and neonatal heart.

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页码：12 / 17

页数：6

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