AZOESTER COMPOUNDS FOR INDUCING DNA CLEAVAGE UNDER PHYSIOLOGICAL CONDITIONS

被引：8

作者：

JEBARATNAM, DJ

KUGABALASOORIAR, S

CHEN, H

ARYA, DP

机构：

[1] Department of Chemistry, Northeastern University, Boston

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 18期

关键词：

D O I：

10.1016/0040-4039(95)00480-Z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

It is demonstrated that azoester compounds are suitable for inducing DNA cleavage under physiological conditions. In particular, ethyl phenydiazenecarboxylate 1 and potassium phenyldiazenecarbosylate 2 have been shown to cleave Phi X174 supercoiled DNA in aqueous buffers of pH=7.2 and 5.2, respectively.

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页码：3123 / 3126

页数：4

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