CHROMOSOMAL LOCALIZATION OF MOUSE AND HUMAN GENES ENCODING THE SPLICING FACTORS ASF/SF2 (SFRS1) AND SC-35 (SFRS2)

被引：15

作者：

BERMINGHAM, JR

ARDEN, KC

NAUMOVA, AK

SAPIENZA, C

VIARS, CS

FU, XD

KHOTZ, J

MANLEY, JL

ROSENFELD, MG

机构：

[1] HOWARD HUGHES MED INST,LA JOLLA,CA 92093

[2] UNIV CALIF SAN DIEGO,DEPT MED,LA JOLLA,CA 92093

[3] TEMPLE UNIV,SCH MED,FELS INST CANC RES,PHILADELPHIA,PA 19140

[4] UNIV CALIF SAN DIEGO,DIV CELLULAR & MOLEC MED,LA JOLLA,CA 92093

[5] COLUMBIA UNIV,DEPT BIOL SCI,NEW YORK,NY 10027

来源：

GENOMICS | 1995年 / 29卷 / 01期

关键词：

D O I：

10.1006/geno.1995.1216

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The mammalian SR-type splicing factors ASF/SF2 and SC-35 play crucial roles in pre-mRNA splicing and have been shown to shift splice site choice in vitro. We have mapped the ASF/SF2 gene in mice and humans and the SC-35 gene in mice. Somatic cell hybrid mapping of the human ASF/SF2 gene (SFRS1 locus) reveals that it resides on chromosome 17, and fluorescence in situ hybridization refines this localization to 17q21.3-q22. Recombinant inbred mapping of the mouse ASF/SF2 gene (Sfrs1 locus) and the mouse SC-35 gene (Sfrs2 locus) demonstrates that both genes are located in a part of mouse chromosome 11 that is homologous to human chromosome 17. Mapping of Sfrs1 using F-1 hybrid backcross mice between the strains C57BL/6 and DDK places Sfrs1 very near the marker D11Mit38 and indicates that the ASF/SF2 gene is closely linked to the Ovum mutant locus. (C) 1995 Academic Press, Inc.

引用

页码：70 / 79

页数：10

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