SYNTHESIS AND PHARMACOLOGICAL PROFILE OF 2 NOVEL HETEROCYCLIC CHROMANOLS, CP-80,798 AND CP-85,958, AS POTENT LTD(4) RECEPTOR ANTAGONISTS

被引：12

作者：

ANDREWS, EG ^{[1
]}

ANTOGNOLI, GW ^{[1
]}

BRESLOW, R ^{[1
]}

CARTA, MP ^{[1
]}

CARTY, TJ ^{[1
]}

CHAMBERS, RJ ^{[1
]}

CHENG, JB ^{[1
]}

COHAN, VL ^{[1
]}

COLLINS, JL ^{[1
]}

DAMON, DB ^{[1
]}

DELEHUNT, J ^{[1
]}

EGGLER, JF ^{[1
]}

ESKRA, JD ^{[1
]}

FREIERT, KW ^{[1
]}

HADA, WA ^{[1
]}

MARFAT, A ^{[1
]}

MASAMUNE, H ^{[1
]}

MELVIN, LS ^{[1
]}

MULARSKI, CJ ^{[1
]}

NACLERIO, BA ^{[1
]}

PAZOLES, CJ ^{[1
]}

PILLAR, JS ^{[1
]}

RAPPACH, LA ^{[1
]}

REICHE, P ^{[1
]}

RUSEK, FW ^{[1
]}

SHERMAN, H ^{[1
]}

SHIRLEY, JT ^{[1
]}

SWEENEY, FJ ^{[1
]}

TICKNER, JE ^{[1
]}

WATSON, JW ^{[1
]}

WRIGHT, CF ^{[1
]}

机构：

[1] PFIZER INC,DIV CENT RES,GROTON,CT 06340

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 13期

关键词：

D O I：

10.1016/0960-894X(95)00225-I

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The development of two novel LTD(4) receptor antagonists as clinical candidates for the treatment of asthma is described. The first generation compound, CP-80,798, was found to be a balanced 5-lipoxygenase inhibitor (5-LOI)/LTD(4) antagonist (LTD(4)-A), while the second generation compound, CP-85,958, is a selective LTD(4) antagonist.

引用

页码：1365 / 1370

页数：6

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