COMPLETE H-1 (600 MHZ) AND C-13 NMR SPECTRAL ASSIGNMENTS OF 3,4-BIS[(3,4-DIMETHOXYPHENYL)-METHYL]DIHYDRO-(3R-TRANS)-2(3H)-FURANONE (MATAIRESINOL DIMETHYL ETHER), A NATURALLY-OCCURRING DIBENZYLBUTYROLACTONE LIGNAN

The concerted applications of a variety of one- and two-dimensional NMR techniques (COSY, NOESY, HETCOR, COLOC, etc.) to the structural elucidation of the natural 3,4-bis[(3,4-dimethoxyphenyl)methyl]dihydro-(3R-trans)-2(3H)-furanone, isolated from Oenanthe aquatica fruits, in CDCl3 Solution are reported. The magnitude of the H-1, H-1 coupling constants obtained from the simulated spectrum together with a series of homonuclear NOE difference spectra were used to determine the full stereochemistry of the system.