Although induction of neural tissue in vertebrates has been recognized since the experiments of Spemann and Mangold seventy years ago, only recently has the phenomenon been put onto a molecular footing. Three molecules, noggin, follistatin and fibroblast growth factor, have been shown to have neuralizing activity in various assays. These assays for neural induction and the molecular mechanisms for the action of neural inducers are reviewed here.
机构:Howard Hughes Medical Institute Program, Excellence in Molecular Biology Cardiovascular Research Inst. Univ. of California, San Francisco, San Francisco
MACNICOL, AM
MUSLIN, AJ
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机构:Howard Hughes Medical Institute Program, Excellence in Molecular Biology Cardiovascular Research Inst. Univ. of California, San Francisco, San Francisco
MUSLIN, AJ
WILLIAMS, LT
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h-index: 0
机构:Howard Hughes Medical Institute Program, Excellence in Molecular Biology Cardiovascular Research Inst. Univ. of California, San Francisco, San Francisco
机构:Howard Hughes Medical Institute Program, Excellence in Molecular Biology Cardiovascular Research Inst. Univ. of California, San Francisco, San Francisco
MACNICOL, AM
MUSLIN, AJ
论文数: 0引用数: 0
h-index: 0
机构:Howard Hughes Medical Institute Program, Excellence in Molecular Biology Cardiovascular Research Inst. Univ. of California, San Francisco, San Francisco
MUSLIN, AJ
WILLIAMS, LT
论文数: 0引用数: 0
h-index: 0
机构:Howard Hughes Medical Institute Program, Excellence in Molecular Biology Cardiovascular Research Inst. Univ. of California, San Francisco, San Francisco