THE EFFECT OF INTERLEUKIN-1 IN RABBIT CERVICAL RIPENING

被引：27

作者：

ELMARADNY, E

KANAYAMA, N

HALIM, A

MAEHARA, K

SUMIMOTO, K

TERAO, T

机构：

[1] Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, 431-31 Hamamatsu, Handa-cho

来源：

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 1995年 / 60卷 / 01期

关键词：

IL-1(BETA); IL-8; COLLAGENASE ACTIVITY; ELASTASE ACTIVITY; NEUTROPHIL; COLLAGEN CONTENT; CERVIX;

D O I：

10.1016/0028-2243(95)02085-3

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: In this research we studied the effect of interleukin-1 beta (IL-1 beta) on the cervix. Study design: Vaginal suppositories of a low dose of IL-1(beta) (200 ng) were applied to non-pregnant and pregnant rabbits. Results were compared with a control group which were treated only by placebo. Water concentration, collagen content, collagenase and elastase activities were measured. Neutrophil numbers in the cervical connective tissue were counted. Also, interleukin-8 (IL-8) was measured in the supernatant of homogenized cervical tissue treated by IL-1(beta). Results: Water contents of the tested cervices were increased (P < 0.006 and 0.03, respectively), whereas collagen content was markedly decreased (P < 0.0004 and 0.001, respectively). Collagenase activity was found to be increased in non-pregnant and pregnant cervices trearted by IL-1(beta) (P < 0.02 and 0.002, respectively). Also, elsatase activity of these cervices were significantly increased compared to the control group (P < 0.0007 and 0.001, respectively). Neutrophil invasion was observed in the cervical connective tissues after application of IL-1(beta). IL-8 was significantly elevated (P < 0.0001) in the treated cervices. Conclusion: Interaction between IL-1 and IL-8 is suspected to be essential for cervical ripening.

引用

页码：75 / 80

页数：6

共 32 条

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