BURIAL OF HYDROCARBON CAUSES COOPERATIVE ENHANCEMENT OF ELECTROSTATIC BINDING

被引：25

作者：

SHARMAN, GJ

SEARLE, MS

BENHAMU, B

GROVES, P

WILLIAMS, DH

机构：

[1] UNIV CAMBRIDGE,CHEM LABS,CAMBRIDGE CTR MOLEC RECOGNIT,CAMBRIDGE CB2 1EW,ENGLAND

[2] UNIV COMPLUTENSE MADRID,FAC CIENCIAS QUIM,DEPT QUIM ORGAN,E-28040 MADRID,SPAIN

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 13-14期

关键词：

ELECTROSTATIC BINDING; HYDROPHOBIC EFFECT; MOLECULAR RECOGNITION; PEPTIDES;

D O I：

10.1002/anie.199514831

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The introduction of alanine methyl groups in adjacent positions on a peptide ligand results in a cooperative enhancement of electrostatic binding from the burial of hydrocarbon. This observation may explain why larger changes in free energy occur when hydrocarbon substituents are buried in a molecular recognition site than can be accounted for by the solvent transfer model (classical hydrophobic effect). Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

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页码：1483 / 1485

页数：3

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