PARATHYROID FUNCTION IN RATS TREATED WITH GROWTH-HORMONE - MORPHOMETRIC STUDY

被引：11

作者：

ALTENAHR, E ^{[1
]}

KAMPF, E ^{[1
]}

机构：

[1] UNIV HAMBURG, INST PATHOL, D-2000 HAMBURG 20, GERMANY

来源：

VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY | 1976年 / 371卷 / 04期

关键词：

D O I：

10.1007/BF00428055

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Male rats weighing 220-250 g were injected i.m. daily with 0.1 mg commercial human growth hormone [GH] for 3 days or 12 days. The serum concentration of total Ca, P and alkaline phosphatase were significantly elevated for some days and returned to normal values at the end of the test period. The parathyroid glands, as studied by light microscopy and EM morphometry showed signs of reduced activity at the 4th day and also at the 13th day: a lowered nucleo-cytoplasmic ratio and a decrease of rough endoplasmic reticulum, of Golgi apparatus and of plasmalemmal tortuosity. The findings suggest a hypercalcemic effect of GH involving peripheral organs of Ca metabolism, especially kidney and bone, and a secondary suppression of parathyroid glands by hypercalcemia.

引用

页码：363 / 371

页数：9

共 33 条

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