PREDICTORS OF DUODENAL-ULCER HEALING DURING TREATMENT WITH CIMETIDINE

被引:9
作者
OKADA, M
YAO, T
MAEDA, K
YAMAMOTO, T
SAIGENJI, K
OKADA, Y
SAKAMOTO, K
TANAKA, K
机构
[1] KITASATO UNIV, SCH MED, DEPT INTERNAL MED, TOKYO 108, JAPAN
[2] FUKUOKA RED CROSS HOSP, DEPT INTERNAL MED, FUKUOKA, JAPAN
[3] FUKUOKA CITY ISHIKAI HOSP, FUKUOKA, JAPAN
关键词
D O I
10.1136/gut.31.7.758
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
A two phase study was performed to identify factors that influence the healing rate of duodenal ulcer. The study included an initial clinical trial in 145 patients and a second trial in a further 61 patients. All patients were prescribed cimetidine at a daily dose of 800 mg for six weeks. The factors examined were age, sex, inpatient or outpatient treatment, duration of present ulcer pain, past history of duodenal ulcer, smoking, drinking, the length of time it took for symptoms to resolve after beginning treatment, and the characteristics of the ulcers themselves. Eighty four per cent of the duodenal ulcers healed after six weeks. Using univariate and multivariate analysis, it was found that three factors indicated a significant delaying effect on healing: (1) symptoms that persisted two weeks after treatment had begun; (2) heavy smoking (20 or more cigarettes daily); and (3) severe narrowing of the duodenal bulb. Patients with none of the three unfavourable factors (n = 90) had a healing rate of 95.6% compared with patients with one (n = 45) or two or more (n = 10) factors, whose healing rates were 75.6% and 20.0% respectively (p < 0.001). The corresponding figures in a second study were 88.9%, 55.0%, and 0%, respectively (p < 0.001). A prognostic score based on these three factors represents the severity of duodenal ulcers with regard to healing in patients treated with cimetidine.
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页码:758 / 762
页数:5
相关论文
共 47 条
[41]  
Snedecor GW, 1967, STATISTICAL METHODS, P381
[42]  
SONNENBERG A, 1981, GASTROENTEROLOGY, V81, P1061
[43]   CIMETIDINE, CIGARETTE-SMOKING, AND RECURRENCE OF DUODENAL-ULCER [J].
SONTAG, S ;
GRAHAM, DY ;
BELSITO, A ;
WEISS, J ;
FARLEY, A ;
GRUNT, R ;
COHEN, N ;
KINNEAR, D ;
DAVIS, W ;
ARCHAMBAULT, A ;
ACHORD, J ;
THAYER, W ;
GILLIES, R ;
SIDOROV, J ;
SABESIN, SM ;
DYCK, W ;
FLESHLER, B ;
CLEATOR, I ;
WENGER, J ;
OPEKUN, A .
NEW ENGLAND JOURNAL OF MEDICINE, 1984, 311 (11) :689-693
[44]  
THOMSON ABR, 1985, BOCKUSGASTROENTEROLO, V2, P1116
[45]  
VALNES K, 1980, SCAND J GASTROENTERO, V15, P65
[46]   SUCRALFATE AND CIMETIDINE AS SINGLE AGENTS AND IN COMBINATION FOR TREATMENT OF ACTIVE DUODENAL-ULCERS - A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].
VANDEVENTER, GM ;
SCHNEIDMAN, D ;
WALSH, JH .
AMERICAN JOURNAL OF MEDICINE, 1985, 79 (2C) :39-44
[47]   TREATMENT OF DUODENAL-ULCER WITH CARBENOXOLONE SODIUM - DOUBLE-MASKED ENDOSCOPIC TRIAL [J].
YOUNG, GP ;
STJOHN, DJB ;
COVENTRY, DA .
MEDICAL JOURNAL OF AUSTRALIA, 1979, 1 (01) :2-5