DELAMINOMYCINS, NOVEL NONPEPTIDE EXTRACELLULAR-MATRIX RECEPTOR ANTAGONIST AND A NEW CLASS OF POTENT IMMUNOMODULATOR .1. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL-ACTIVITY

被引：15

作者：

UENO, M

AMEMIYA, M

IIJIMA, M

OSONO, M

MASUDA, T

KINOSHITA, N

IKEDA, T

IINUMA, H

HAMADA, M

ISHIZUKA, M

TAKEUCHI, T

机构：

[1] MICROBIAL CHEM RES FDN,INST CHEMOTHERAPY,18-24 AZA MOTONO,NUMAZU,SHIZUOKA 41003,JAPAN

[2] MICROBIAL CHEM RES FDN,INST MICROBIAL CHEM,SHINAGAWA KU,TOKYO 141,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 05期

关键词：

D O I：

10.7164/antibiotics.46.719

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In order to develop a new class of immunomodulator we have searched for a low molecular weight inhibitors of cell adhesion to components of extracellular matrix (ECM), fibronectin (FN), laminin (LM) and collagen type IV (CL), and succeeded to find a group of novel antibiotics, named delaminomycins. Delaminomycins were isolated from the mycelium and cultured broth of Streptomyces albulus MJ202-72F3. It was purified by use of centrifugal partition chromatography (CPC), preparative reverse phase HPLC and Sephadex LH-20 and was obtained as a white powder. Delaminomycins with inhibitory activity for cell adhesion to ECM components suppressed immune responses in vitro and in vivo and exhibited antimicrobial activity on Gram-positive bacteria.

引用

页码：719 / 727

页数：9

共 16 条

[11] BATROXOSTATIN, AN ARG-GLY-ASP-CONTAINING PEPTIDE FROM BOTHROPS-ATROX, IS A POTENT INHIBITOR OF PLATELET-AGGREGATION AND CELL-INTERACTION WITH FIBRONECTIN [J].