SYNTHESIS OF DOUBLY CROSS-LINKED CYCLIC HEXAPEPTIDES

被引：2

作者：

BAILEY, PD ^{[1
]}

CARTER, SR ^{[1
]}

CLARKE, DGW ^{[1
]}

CROFTS, GA ^{[1
]}

TYSZKA, JHM ^{[1
]}

SMITH, PW ^{[1
]}

WARD, P ^{[1
]}

机构：

[1] GLAXO GRP RES LTD,GREENFORD UB6 0HE,MIDDX,ENGLAND

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(00)79854-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cyclic hexapeptides in which the adjacent N(epsilon)-nitrogens of cyclo-(Lys-Lys-Gly)2 are cross-linked by p-xylyl or (CH2)6 units have been prepared. The key steps in the syntheses of these novel types of peptide were the use of tosyl (or, less efficiently, trifluoroacetyl) as N(epsilon)-protection that allowed intramolecular cross-linking of the tripeptides Boc-Lys(R)-Lys(R)-Gly-OMe (R = Ts or CF3CO) using alpha,omega-dibromo-alkanes/ Cs2CO3, and the efficient cyclo-dimerisation of the pentafluoro-phenyl esters of the resultant cross-linked tripeptides.

引用

页码：3211 / 3214

页数：4

共 5 条

[1] SYNTHESIS OF A CYCLIC PEPTIDE POLYAMINE - A COMPARATIVE-STUDY OF ROUTES TO CYCLO-(LYS-LYS-GLY)2 [J].