SYNTHESIS OF POLYCYCLIC HEXAPEPTIDES CONTAINING MULTIPLE INTRAMOLECULAR CROSS-LINKS

被引：1

作者：

BAILEY, PD ^{[1
]}

CARTER, SR ^{[1
]}

CLARKE, DGW ^{[1
]}

CROFTS, GA ^{[1
]}

SMITH, PW ^{[1
]}

WARD, P ^{[1
]}

机构：

[1] GLAXO GRP RES LTD,GREENFORD UB6 0HE,MIDDX,ENGLAND

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(00)79855-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two polycyclic peptides have been prepared in which all four of the epsilon-nitrogens of cyclo-(Lys-Lys-Gly)2 are interconnected by intra-molecular cross-links. One of these compounds possessed (CH2)6 units between the adjacent lysyl residues and 4,4'-dimethylenebiphenyl units between the skipped lysyl residues, whilst the other contained p-xylyl units between all four of the lysyl residues.

引用

页码：3215 / 3218

页数：4

共 5 条

[1] SYNTHESIS OF DOUBLY CROSS-LINKED CYCLIC HEXAPEPTIDES [J].